The southern rapper's project contains 14 tracks without features from any other artists.
"Issa" featuring Drake and Young Thug leaked in May, and some of 21's fans were expecting the title track to be included on Issa Album.
After the song was excluded from the final tracklist, there was hope that a high-quality version would eventually be released.
That prospect was shut down by 21's manager Kei Henderson.
When asked on Twitter "So we never getting a CDQ version of Issa with Drake and Thug?" Henderson simply responded, "Nope."
"Issa" will apparently remain in the vault, but 21 Savage followers are gravitating toward another record.
The Slaughter Gang leader's "Bank Account" is currently in the Top 10 on iTunes' Hip-Hop/Rap chart and in the Top 15 on Spotify's Top 200 U.S. chart.