Cee-Lo will play the role of Troublegum, a well-known and very successful Hip-Hop star, a familiar notion for the Gnarls Barkley and Goodie Mob member.
The film, produced by Exclusive Media, also stars fellow The Voice judge, Adam Levine (Maroon 5), Keira Knightley (Pirate of the Caribbean), Mark Ruffalo (The Avengers), Hailee Steinfeld (True Grit), and Catherine Keener (40 Year Old Virgin).
Production on Can A Song Save Your Life? is set to begin next week in New York City.
Currently, Cee-Lo is working with Goodie Mob on the group's forthcoming, fifth studio album, Age Against the Machine and despite earlier complaints about the show, he will return as a judge on the third season of NBC's hit, singing competition, "The Voice", this fall.
He will also call Las Vegas home for the next few months during his Planet Hollywood residency of Cee-Lo Green Presents "Loberace."